Digestion, Mood and the Gut-Brain Connection

Product Description

Your Gut Has 500 Million Neurones. It Is Talking to Your Brain More Than Your Brain Is Talking to It.

The vagus nerve carries 80% of its signals upward — from gut to brain. The gut produces 90–95% of the body’s serotonin. The gut microbiome generates the GABA that reduces anxiety. And the leaky gut of dysbiosis drives the neuroinflammation that produces the depression, brain fog, and cognitive dulling that no one is treating at its source.

Digestion, Mood and the Gut-Brain Connection is the most clinically integrated guide in the Gut-Brain Series — covering the neurogastroenterology, the gut-mental health evidence, and the practical protocol for addressing gut and brain simultaneously.

What This Guide Covers

Chapter 1 — Neurogastroenterology: The enteric nervous system — 500 million neurones, the migrating motor complex, interstitial cells of Cajal, and enteroendocrine cells. The four gut-brain pathways: neural (vagus), hormonal (HPA axis), immune (LPS-cytokine-neuroinflammation), and biochemical (SCFAs, tryptophan metabolites, bile acids). Visceral hypersensitivity: the central sensitisation mechanism that makes the IBS gut hurt more than it should.

Chapter 2 — IBS: Rome IV criteria, subtypes (IBS-D, IBS-C, IBS-M, post-infectious), the mast cell connection, SIBO co-morbidity. The treatment hierarchy — from low FODMAP to peppermint oil to gut-directed hypnotherapy to low-dose TCA — with evidence grades for each.

Chapter 3 — Gut and Mood: The inflammatory theory of depression. The kynurenine pathway — how gut inflammation shunts tryptophan away from serotonin toward neurotoxic quinolinic acid. The SMILES trial (Mediterranean diet achieving 31.9% depression remission vs 8% control). The Valles-Colomer data: specific species (Coprococcus, Dialister) depleted in depression in 1,054-person population study.

Chapter 4 — Anxiety, Stress and the Gut: CRH and mast cell activation — the mechanism by which psychological stress produces immediate gut hypersensitivity. The gut-anxiety vicious circle. Evidence-based psychological interventions: gut-directed hypnotherapy (70–75% IBS response rate, durable at 5 years), CBT, MBSR, diaphragmatic breathing.

Chapter 5 — The Serotonin System: EC cell serotonin production and its microbiome drivers. 5-HTP supplementation — the evidence, the protocol, the cautions. Serotonin’s role in peristalsis, visceral sensation, and why SSRIs affect gut function as a class effect.

Chapter 6 — Dietary Interventions: Mediterranean diet for mood. Omega-3 EPA for neuroinflammation (the 2019 JAMA Open Network meta-analysis). Low FODMAP, peppermint oil, and soluble fibre for IBS. Meal composition and timing for gut-brain health.

Chapter 7 — Psychobiotics: The human evidence for mood and anxiety effects from specific strains: Bifidobacterium longum 1714, Lactobacillus helveticus R0052 + Bifidobacterium longum R0175, Bifidobacterium infantis 35624. The prebiotic FOS+GOS combination and morning cortisol. Targeted supplements: L-glutamine, zinc carnosine, magnesium glycinate, ashwagandha KSM-66.

Chapter 8 — The 12-Week Protocol: Four phases covering dietary foundation, HPA management, psychobiotic introduction, and psychological integration (including access to gut-directed hypnotherapy).

Who This Guide Is For

• Individuals with IBS who want to understand and treat the gut-brain connection, not just manage symptoms
• People with depression or anxiety who suspect a gut component they haven’t addressed
• Anyone with post-meal brain fog, afternoon energy crashes, or mood that tracks with gut comfort
• Those who have tried SSRIs or CBT without full resolution and want to add gut-targeted interventions
• Healthcare professionals wanting the evidence base for gut-brain integrated care

What Makes This Different

The Bravo et al. GABA-vagus mechanism. The Parkinson’s gut-first hypothesis. The SMILES trial in full. The SIGHI histamine intolerance protocol. Post-COVID gut-brain dysregulation. Case studies including the executive with IBS-D and the student with gut-driven depression. This is the guide that explains why the gut-brain connection works — not just that it does.

65 pages. Evidence-based. Instant PDF download.

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SEO TITLE: Digestion, Mood and the Gut-Brain Connection – Evidence-Based IBS & Mental Health Guide | 65pp PDF SEO META: The complete evidence-based guide to IBS, gut-driven mood, and the gut-brain axis. Covers psychobiotics, serotonin, low FODMAP, gut-directed hypnotherapy, and the 12-week Gut-Brain Protocol. FOCUS KEYPHRASE: gut brain connection guide

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